Syzygium aromaticum (L.) elicits lifespan extension and attenuates age-related Aβ-induced proteotoxicity in Caenorhabditis elegans
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چکیده
منابع مشابه
Syzygium aromaticum (L.) elicits lifespan extension and attenuates age-related Aβ-induced proteotoxicity in Caenorhabditis elegans
Clove (Syzygium aromaticum) is a popular medicinal plant which has been traditionally used in India as spice and medicine to counter various ailments. However, the stress modulatory and antiaging potential of this plant is yet to be characterized. Therefore, the present study evaluates the effect of clove oil (CO) on oxidative stress, lifespan, mobility, and the expression of aging-related prot...
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Many conditions that shift cells from states of nutrient utilization and growth to states of cell maintenance extend lifespan. We have carried out a systematic lifespan analysis of conditions that inhibit protein synthesis. We find that reducing the levels of ribosomal proteins, ribosomal-protein S6 kinase or translation-initiation factors increases the lifespan of Caenorhabditis elegans. These...
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One goal of aging research is to find drugs that delay the onset of age-associated disease. Studies in invertebrates, particularly Caenorhabditis elegans, have uncovered numerous genes involved in aging, many conserved in mammals. However, which of these encode proteins suitable for drug targeting is unknown. To investigate this question, we screened a library of compounds with known mammalian ...
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ژورنال
عنوان ژورنال: Cogent Biology
سال: 2016
ISSN: 2331-2025
DOI: 10.1080/23312025.2016.1218412